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Review Article | OPEN ACCESS

Recent novel tumor gatekeepers and potential therapeutic approaches (2017)

Kashif Rafiq Zahid1, Hira Khan Zada2, Ghulam Mustafa Wassan2, Waseem Hassan3, Ke Liu1, Yanli Liu1, Jinlin Liu1, Haobin Zhao1, Chao Qi1

1Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Central China Normal University, Wuhan 430079, PR China; 2Department of Plant Breeding and Genetics, Sindh Agriculture University, Tandojam, 3Department of Soil and Environmental Sciences, Muhammad Nawaz Shareef University of Agriculture, Multan, Pakistan.

For correspondence:-  Chao Qi   Email: qichao@mail.ccnu.edu.cn

Accepted: 20 September 2017        Published: 31 October 2017

Citation: Zahid KR, Zada HK, Wassan GM, Hassan W, Liu K, Liu Y, et al. Recent novel tumor gatekeepers and potential therapeutic approaches (2017). Trop J Pharm Res 2017; 16(10):2545-2553 doi: 10.4314/tjpr.v16i10.31

© 2017 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Tumor remains a challenging task for oncology community. Drug resistance due to chemotherapy remain principal impediments toward potential therapeutic strategies. Development of novel anti-cancer drugs or new targeted strategies to conquer drug resistance is a key goal of cancer research. In this respect, novel tumor gatekeepers and innovative targeted strategies can be helpful in overcoming drug resistance as well as improve currently used targeted therapies. In this review, efforts have been made to present some of the latest knowledge about novel tumor gatekeepers and new therapeutic strategies to improve the efficacy of chemotherapy and give new hope to cancer patients to fight against cancer
 

Keywords: Cancer, Potent inhibitors, Gatekeepers, Therapeutic approaches, Oncogenic pathways

Impact Factor
Thompson Reuters (ISI): 0.523 (2021)
H-5 index (Google Scholar): 39 (2021)

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